A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.
نویسندگان
چکیده
A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent columns to effect bifurcation of the reaction pathway.
منابع مشابه
A CFD Simulation of Hydrogen Production in Microreactors
In this study, the modeling of hydrogen production process in microreactors by methanol-steam reforming reaction is investigated. The catalytic reaction of methanol-steam reforming producing hydrogen is simulated considering a 3D geometry for the microreactor. To calculate diffusion among species, mixture average correlations are compared to Stephan-Maxwell equations. The reactions occurring in...
متن کاملBiodiesel production from soybean oil using ionic liquid as a catalyst in a microreactor
In the present study, Choline hydroxide (ChOH) as an ionic liquid catalyst was used for transesterification of soybean oil into biodiesel in a microchannel reactor. The effects of three variables i.e. reaction temperature, catalyst dosage and total flow rate on fatty acid methyl ester (FAME) content (wt. %) were optimized using Box–Behnken experimental design. In order to predict the FAME conte...
متن کاملSingle Step and Non-Catalytic Process for Formaldehyde Production from Methane using Microchannel Reactor: Theoretical Analysis
Conventionally, methane is reformed into syngas, and subsequently converted into C1-oxygenates (methanol and formaldehyde). A novel option is the catalyst-free single-step conversion of methane to C1-oxygenates. This study presents a comprehensive model of methane partial oxidation to formaldehyde as an intermediate chemical species in methane oxidation process using microreactor. The dependenc...
متن کاملDirect preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes.
A range of heterocycles, namely thiazoles, imidazoles, imidazopyridines, thiazolidines and dimethoxyindoles, have been synthesised directly from alkenes via a two-step ketoidoination/cyclisation protocol. The alkene starting materials are themselves readily accessible using many different and well-established approaches, and allow access to a variety of heterocycles with excellent yields and re...
متن کاملOrganocatalytic strategies for the construction of optically active imidazoles, oxazoles, and thiazoles.
This study demonstrates the first enantioselective synthesis of hydroxyalkyl- and aminoalkyl-substituted imidazoles, oxazoles, and thiazoles. The approach developed utilizes a highly effective one-pot reaction cascade that consists of either an organocatalytic epoxidation or aziridination of α,β-unsaturated aldehydes coupled with a [3+2]-annulation, in which amidines, ureas, or thioureas act as...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of combinatorial chemistry
دوره 10 6 شماره
صفحات -
تاریخ انتشار 2008